Building a Better Test for Piperacillin-Tazobactam Susceptibility Testing: Would that It Were So Simple (It's Complicated)

Tazocin (Piperacillin-tazobactam) Susceptibility Pattern in Nosocomial Infections

Background & Aims: Utility of antibiotics, such as third and fourth generation of cephalosporins and carbapenems, and resistance to these antibiotics in hospital acquired infections are increased. There are scientific data that support the application of Tazocin (piperacillin-tazobactam) as an empirical treatment of moderate to severe bacterial infections. In our area there is not much informat...

Accuracy of automated and manual systems for susceptibility testing of Pseudomonas aeruginosa to piperacillin and piperacillin-tazobactam.

This study aimed to evaluate the accuracy of routine systems (Vitek2 cards AST-N022 and AST-N026; Kirby Bauer; Etest) for susceptibility testing of Pseudomonas aeruginosa to piperacillin and piperacillin-tazobactam. Vitek2 (card AST-N022) showed the worst performance; the other three methods (Vitek2 card AST-N026, Kirby-Bauer and E-test) performed comparably but never fulfilled the minimal stan...

Piperacillin and Tazobactam for Injection

CLINICAL PHARMACOLOGY Adults Peak plasma concentrations of piperacillin and tazobactam are attained immediately after completion of an intravenous infusion of Piperacillin and Tazobactam for Injection. Piperacillin plasma concentrations, following a 30 minute infusion of Piperacillin and Tazobactam for Injection, were similar to those attained when equivalent doses of piperacillin were administ...

Population strategies for prevention? If only it were that simple!

Piperacillin/tazobactam Induced Myelosuppression

UNLABELLED Neutropenia, secondary to immune destruction or maturation arrest, is the most commonly described adverse haematological effect of beta-lactam antibiotics. We describe a case of reversible pancytopenia, with evidence of hypocellular marrow, after a prolonged course of piperacillin/tazobactam for 26 days. KEYWORDS Piperacillin; Tazobactam; Myelosuppression; Neutropenia.